Neuroimaging and cognitive changes during deja vu

Kovács, Norbert and Auer, Tibor and Balás, István and Karádi, Kázmér and Zámbó, Katalin and Schwarcz, Attila and Klivényi, Péter and Horváth, Krisztina and Nagy, Ferenc and Janszky, József and Jokeit, Hennric (2009) Neuroimaging and cognitive changes during deja vu. EPILEPSY & BEHAVIOR, 14 (1). pp. 190-196. ISSN 1525-5050

Text 2009_EB_DejaVu.pdf Restricted to Registered users only Download (516kB) | Request a copy

Abstract

Objective: The cause or the physiological role of de?ja? vu (DV) in healthy people is unknown. The pathophysiology of DV-type epileptic aura is also unresolved. Here we describe a 22-year-old woman treated with deep brain stimulation (DBS) of the left internal globus pallidus for hemidystonia. At certain stimulation settings, DBS elicited reproducible episodes of DV. Methods: Neuropsychological tests and single-photon-emission computed tomography (SPECT) were performed during DBS-evoked DV and during normal DBS stimulation without DV. Results: SPECT during DBS-evoked DV revealed hyperperfusion of the right (contralateral to the electrode) hippocampus and other limbic structures. Neuropsychological examinations performed during several evoked DV episodes revealed disturbances in nonverbal memory. Conclusion: Our results confirm the role of mesiotemporal structures in the pathogenesis of DV. We hypothesize that individual neuroanatomy and disturbances in gamma oscillations or in the dopaminergic system played a role in DBS-elicited DV in our patient. ? 2008 Elsevier Inc. All rights reserved.

Actions (login required)

Edit Item