Visuospatial impairment in Parkinson's disease: The role of laterality

Karádi, Kázmér and Lucza, Tivadar and Aschermann, Zsuzsanna and Komoly, Sámuel and Deli, Gabriella and Ács, Péter and Horváth, Réka and Janszky, József Vladimír and Kovács, Norbert (2015) Visuospatial impairment in Parkinson's disease: The role of laterality. LATERALITY, 20 (1). pp. 112-127. ISSN 1357-650X

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Abstract

Asymmetry is one of the unique and mysterious features of Parkinson ’ s disease (PD). Motor symptoms develop unilaterally either on the left (LPD) or the right side (RPD). Incongruent data are available whether the side of onset has an impact on cognition in PD. The objective of this study is to compare the visuospatial performance of RPD and LPD patients. Seventy-one non-demented, non-depressive and right-handed patients were categorized into RBD ( n = 36) and LPD ( n = 35) groups. Rey-Osterrieth Complex Figure Test (ROCF) was evaluated by both the Taylor ’ s and Loring ’ s scoring systems. Subsequently, we also performed subgroup analyses on patients having short disease duration ( ≤ 5 years, 15 RBD and 15 LPD patients). The standard analysis of ROCF (Taylor ’ s system) did not reveal any differences; however, the utilization of the Loring ’ s system demonstrated that LPD patients had significantly worse visuospatial performance than the RPD subjects (3.0 vs. 2.0 points, median, p = 0.002). Correlation between the number of spatial errors and the degree of asymmetry was significant ( r = − 0.437, p = 0.001). However, this difference could not be observed in PD patients with short disease duration. LPD patients had worse visuospatial performance than the RPD subjects and the number of errors tightly correlated with the degree of asymmetry and long disease duration.

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