Proton radiation impairs mechanotransduction in C2C12 myoblasts

Gere, Áron Károly and Szabó, László and Tillmann, Brigitta and Balogh, Csaba and Zákány, Florina and Kovács, Tamás and Nagy, Péter and Szarka, Máté and Csernoch, László and Dienes, Beatrix (2026) Proton radiation impairs mechanotransduction in C2C12 myoblasts. NPJ MICROGRAVITY, 12. No. 67. ISSN 2373-8065

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Abstract

Skeletal muscle dysfunction during spaceflight arises from combined mechanical and non-gravitational stressors. Here, we modeled solar particle event-like proton irradiation in C2C12 myogenic cells to examine radiation-induced membrane and mechanosensitive channel alterations. Proton exposure increased membrane rigidity in a dose-dependent manner and significantly reduced the pharmacological activatability of Piezo1 channels, identifying membrane-mediated mechanotransduction as a potential contributor to radiation-induced muscle dysfunction.

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