Changes of para-, meta- and ortho-tyrosine over time in burned patients

Kovács, Patricia and Szélig, Lívia and Kun, Szilárd and Loibl, Csaba and Woth, Gábor László and Molnár, Gergő Attila and Wittmann, István and Bogár, Lajos and Miseta, Attila János and Csontos, Csaba (2020) Changes of para-, meta- and ortho-tyrosine over time in burned patients. IMMUNOBIOLOGY, 225 (3). ISSN 0171-2985

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Abstract

Purpose: Serious burn injury leads to oxidative stress resulting in production of meta- and ortho-tyrosine, while para-tyrosine is the physiological isoform. Our aim was to investigate the metabolism of these tyrosine isoforms following major burn injury. Methods: Fifteen patients requiring intensive care were followed for 5 consecutive days after major burn injury. Serum and urine concentrations of para-, meta-, and ortho-tyrosine were measured with high performance liquid chromatography. Fifteen healthy matching individuals were invited as control group. Results: Median serum concentration of normal isoform para-tyrosine decreased in burned patients between days 2 and 5 (p < 0.01). Mean meta-, and ortho-tyrosine levels were significantly higher in patients compared to controls in the same time period (p < 0.05). Renal excretion of para-tyrosine increased significantly in our observation period (p < 0.01). Conclusions: Pathologic isoforms of tyrosine accumulate in serum meanwhile the level of normal isoform decreases possibly due to belated enhanced renal excretion or, to decreased synthesis after major burn injury

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