The effects of pituitary adenylate cyclase activating polypeptide in renal ischemia/reperfusion

László, Eszter and Kiss, Péter and Horváth, Gabriella and Szakály, Péter and Tamás, Andrea and Reglődi, Dóra (2014) The effects of pituitary adenylate cyclase activating polypeptide in renal ischemia/reperfusion. ACTA BIOLOGICA HUNGARICA, 65 (4). pp. 369-378. ISSN 0236-5383

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Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP ) is a multifunctional neuropeptide occurring in the nervous system as well as in the peripheral organs. Beneficial action of PACAP has been shown in different pathological processes. The strong protective effects of the peptide are probably due to its complex modulatory actions in antiapoptotic, anti-inflammatory and antioxidant pathways. In the kidney, PACAP is protective in models of diabetic nephropathy, myeloma kidney injury, cisplatin-, gentamycinand cyclosporin-induced damages. Numerous studies have been published describing the protective effect of this peptide in renal ischemia/reperfusion. The present review focuses on the ischemia/reperfusioninduced kidney injury and gives a brief summary about the results published in this area.

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