4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study.

Madách, Krisztina and Aladzsity, István and Szilágyi, Agnes and Fust, George and Gál, János and Pénzes, István and Prohászka, Zoltán (2010) 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. Critical care (London, England), 14 (2). R79. ISSN 1466-609X

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Abstract

In Caucasian patients with severe sepsis due to pneumonia carriers of the 4G allele of PAI-1 polymorphism have higher risk for multiple organ dysfunction syndrome and septic shock and in agreement they showed more fulminant disease progression based on continuous clinical variables.

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