Effect of mycophenolate mofetil on the in vivo infiltration of lymphocytes in the rat remnant kidney.

Müller, Veronika and Hamar, Péter and Szabó, Attila József and Knust, E. and Vogelsang, Magdalene and Heemann, Uwe (1998) Effect of mycophenolate mofetil on the in vivo infiltration of lymphocytes in the rat remnant kidney. Transplantation proceedings, 30 (4). p. 982. ISSN 0041-1345

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Abstract

THE DEVELOPMENT of progressive glomerulosclerosis in hyperfiltrating kidneys has been ascribed to a number of humoral and hemodynamic factors, including the upregulation of adhesion molecules and subsequent infiltration of leukocytes into the damaged tissue. Mycophenolate mofetil (MMF) is a new immunosuppressant that selectively inhibits the proliferation of lymphocytes and additionally downregulates the expression of adhesion molecules in vitro. In this study, we investigated the influence of a short-term pretreatment with MMF on the in vivo migration pattern of lymphocytes in a rat model of hyperfiltration.

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