Utilization of Copper-Catalyzed Carboarylation−Ring Closure for the Synthesis of New Oxazoline Derivatives

Sinai, Ádám and Vangel, Dóra and Gáti, Tamás and Bombicz, Petra and Novák, Zoltán (2015) Utilization of Copper-Catalyzed Carboarylation−Ring Closure for the Synthesis of New Oxazoline Derivatives. Organic Letters. ISSN 1523-7060

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Abstract

A copper-catalyzed carboarylation−ring-closure strategy was used for the modular synthesis of oxazolines via the reaction of 1-aryl- and 1-alkylpropargylamides and diaryliodonium salts. The novel approach enables the efficient, modular synthesis of oxazoline derivatives bearing fully substituted exo double bonds.

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