Intrinsically disordered proteins: Emerging interaction specialists

Tompa, Péter and Schád, Éva and Tantos, Ágnes and Kalmár, Lajos (2015) Intrinsically disordered proteins: Emerging interaction specialists. CURRENT OPINION IN STRUCTURAL BIOLOGY, 35. pp. 49-59. ISSN 0959-440X

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Abstract

Intrinsically disordered proteins or regions of proteins (IDPs/IDRs) most often function through protein-protein interactions, when they permanently or transiently bind partner molecules with diverse functional consequences. There is a rapid advance in our understanding of the ensuing functional modes, obtained from describing atomic details of individual complexes, proteome-wide studies of interactomes and characterizing loosely assembled hydrogels and tightly packed amyloids. Here we briefly survey the most important recent methodological developments and structural-functional observations, with the aim of increasing the general appreciation of IDPs/IDRs as 'interaction specialists'. © 2015 Elsevier Ltd.

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