Application of atomic force microscopy for investigation of Na⁺,K⁺-ATPase signal-transducing function

Khalisov, MM and Ankudinov, AV and Penniyaynen, VA and Dobrota, D and Krylov, Boris V. (2015) Application of atomic force microscopy for investigation of Na⁺,K⁺-ATPase signal-transducing function. Acta Physiologica Hungarica, 102 (2). pp. 125-130. ISSN 0231-424X

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Abstract

The Young’s modulus of 10–12-day-old chick embryos’ sensory neurons cultivated in dissociated cell culture was measured using a PeakForce Quantitative Nanomechanical Mapping atomic force microscopy. The native cells were tested in control experiments and after application of ouabain. At low “endogenous” concentration of 10⁻¹⁰ M, ouabain tended to increase the rigidity of sensory neurons. We hypothesize that this trend resulted from activation of Na⁺,K⁺-ATPase signal-transducing function.

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