Nanoparticle formation of chitosan induced by 4-sulfonatocalixarenes: Utilization for alkaloid encapsulation

Harangozó, József G. and Wintgens, Veronique and Miskolczy, Zsombor and Amiel, Catherine and Biczók, László (2016) Nanoparticle formation of chitosan induced by 4-sulfonatocalixarenes: Utilization for alkaloid encapsulation. Colloid and Polymer Science. ISSN 0303-402X (In Press)

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Abstract

Spontaneous formation of positively charged nanoparticles was observed upon mixing more than stoichiometric amount of chitosan with 4-sulfonatocalix[8]arene (SCX8) in acidic solution. The particle size did not change with SCX8 concentration, polymer chain length and the degree of deacetylation at 0.002 ≤ SCX8:chitosan ≤ 0.043 molar ratios in 0.01 M HCl. However, larger aggregates were produced when chitosan concentration was increased. The most stable nanoparticles with 160 nm diameter and narrow size distribution were obtained at pH 4 using low molecular weight chitosan. These particles encapsulated coralyne with more than 90% entrapment efficiency and 15% loading capacity. A loading ratio of [coralyne]/[SCX8] = 1.7 was achieved without any stability loss. 4-Sulfonatocalix[4]arene induced the formation of slightly smaller nanoparticles than its homologues comprising 6 or 8 phenol units.

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