Diterpene constituents of Euphorbia exigua L. and multidrug resistance reversing activity of the isolated diterpenes

Rédei, Dóra and Boros, Klára and Forgó, Péter and Kele, Zoltán and Pálinkó, István and Pinke, Gyula and Hohmann, Judit (2015) Diterpene constituents of Euphorbia exigua L. and multidrug resistance reversing activity of the isolated diterpenes. CHEMISTRY & BIODIVERSITY, 12 (8). pp. 1214-1221. ISSN 1612-1872

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Abstract

Phytochemical investigation of the MeOH extract obtained from the aerial parts of the annual weed Euphorbia exigua L. resulted in the isolation of two novel (1, 2) and one known (3) jatrophane diterpenes. Their structures were established by extensive 1D- and 2D-NMR spectroscopy and HR-ESIMS. The isolated compounds were evaluated for multidrug resistance (MDR) reversing activity on human MDR gene-transfected L5178 mouse lymphoma cells; and all three compounds were found to modulate the intracellular drug accumulation.

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