Application of g-Valerolactone as an Alternative Biomass-Based Medium for Aminocarbonylation Reactions

Marosvölgyi-Haskó, Diána and Kollár, László and Lengyel, Blanka and Tukacs, József M. and Mika, László Tamás (2015) Application of g-Valerolactone as an Alternative Biomass-Based Medium for Aminocarbonylation Reactions. ChemPlusChem, 87. pp. 1-7. ISSN 2192-6506 (In Press)

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Abstract

g-Valerolactone (GVL) was proposed as a renewable, nontoxicreaction medium with negligible vapor pressure for homoge-neous Pd-catalyzed aminocarbonylation reactions. Iodoben-zene as a model substrate and its 4-substituted derivativeswere converted to the corresponding 2-ketocarboxamides withhigh conversions and chemoselect ivities in g-valerolactone.The effect of carbon monoxide pressure and reaction tempera-ture on the conversion and selectivities were studied in therange 1–50 bar and 25–1008C, respectively. The highest con-version and selectivity was achieved at 25 bar and 50 8C for io-dobenzene in GVL for 24 h.

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