Indometacin loading and in vitro release properties from novel carbopol coated spherical mesoporous silica nanoparticles

Tzankov, Borislav and Yonchevaa, Krassimira and Popova, Margarita and Szegedi, Ágnes and Momekov, Georgi and Mihály, Judith and Lambov, Nicolai (2013) Indometacin loading and in vitro release properties from novel carbopol coated spherical mesoporous silica nanoparticles. MICROPOROUS and Mesoporous Materials, 171. pp. 131-138. ISSN 1387-1811

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Abstract

Spherical MCM-41 silica nanosized particles were synthesized and post synthesis modified by 3-aminopropyltriethoxysilane (APTES) in order to prepare amino-functionalized carrier. Both types of silica particleswere loaded with indometacin and further coated with carbopol. The preservation of morphology and pore structure of the particles was observed by XRD, TEM and N2 physisorption. FT-IR spectroscopy revealed the interaction between carboxyl groups of indometacin and the amino groups of the functionalized MCM-41. Amino-functionalization of the carrier resulted in higher degree of indometacin loading in comparison to the parent MCM-41, 39% vs. 30%, respectively. The coating of drug loaded amino-MCM-41 silica particles with carbopol significantly reduced the initial burst release of indometacin. Both silica carriers demonstrated no cytotoxicity on HL-60 (acute myeloid leukemia) and K-562 (chronic myeloid leukemia) cell lines.

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