Kovacs, Dávid and Kovács, Péter and Eszlari, Nora and Gonda, Xénia and Juhász, Gabriella (2016) Psychological side effects of immune therapies: symptoms and pathomechanism. CURRENT OPINION IN PHARMACOLOGY, 29. pp. 97-103. ISSN 1471-4892
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Abstract
Immunotherapies revolutionised the treatment of several disorders but show specific side-effect profiles which frequently involve psychological symptoms. Long term interferon-alpha (IFN-alpha) therapy can cause wide-ranging psychiatric side-effects from fatigue, insomnia, anxiety to full-blown depression. This treatment-emergent depression shares several symptoms with major depressive disorder (MDD) with a predominance of somatic/neurovegetative symptoms, and can be treated with antidepressants. However, this experience directed research to inflammatory mechanisms in MDD. MDD has been confirmed as a heterogeneous disorder with a subgroup of patients suffering from low-grade chronic inflammation and frequently resistant to traditional antidepressant treatment. Thus future research should develop strategies to identify those MDD patients who could benefit from drugs acting through inflammatory pathways.
| Item Type: | Article |
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| Subjects: | R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan |
| Depositing User: | Prof. György Bagdy |
| Date Deposited: | 09 Feb 2017 13:44 |
| Last Modified: | 04 Apr 2023 12:17 |
| URI: | http://real.mtak.hu/id/eprint/47809 |
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