The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds

Bana, Péter and Örkényi, Róbert Zoltán and Lövei, Klára and Lakó, Ágnes and Túrós, György István and Faigl, Ferenc and Éles, János and Greiner, István (2016) The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds. BIOORGANIC & MEDICINAL CHEMISTRY. Article in Press. ISSN 0968-0896

Preview

Text BMCL_2016_Faigl.pdf Download (2MB) | Preview

Abstract

Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing processes of pharmaceutical compounds, in accordance with recent regulatory, economical and quality guidances. The chemical and technical knowledge gained during these studies is considerable; nevertheless, connecting several individual chemical transformations and the attached analytics and purification holds hidden traps. In this review, we summarize innovative solutions for these challenges, in order to benefit chemists aiming to exploit flow chemistry systems for the synthesis of biologically active molecules. © 2016 Elsevier Ltd.

Actions (login required)

Edit Item