Selective apoptotic behaviour of bovine herpesvirus 1 in an epithelial-like microenvironment

Baskin, Yasemin and Yazici, Z. and Baskin, H. and Ozkul, A. and Olgun, Nur and Bahar, I. H. (2005) Selective apoptotic behaviour of bovine herpesvirus 1 in an epithelial-like microenvironment. Acta Veterinaria Hungarica, 53 (4). pp. 479-491. ISSN 0236-6290

Preview

Text avet.53.2005.4.8.pdf Download (417kB) | Preview

Abstract

Apoptosis seems to play an important role in the pathogenic profile of bovine herpesvirus 1 (BHV-1) infection. Nitric oxide (NO) is also important as a signal molecule. In this study, apoptosis was selectively induced in HEp-2 cells in the early stage [1-3 h postinfection (PI)] of BHV-1 multiplication, and this apoptotic process was realised through the caspase-8, and partially through the caspase-3, pathway. BHV-1 infection inhibited staurosporine- (SS-) induced apoptosis only if the SS was added at 6 h PI. The results of this study showed that the 'NO-apoptosis' relation was realised through the caspase-8 pathway ('outer membrane receptor' pathway) at a later stage of infection in apoptosis induced by BHV-1 + SS. Our previous report (Yazici et al., 2004) and this study together showed that BHV-1 might induce and inhibit cell-type-specific pathways of apoptosis.

Actions (login required)

Edit Item