Shirahata, T. (2014) Effect of sodium conductance variations on electrical behavior of a neocortical neuron model. Acta Biologica Hungarica, 65 (4). pp. 379-384. ISSN 0236-5383
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Abstract
Neocortical pyramidal neurons are capable of intrinsic regenerative firing. A mathematical model introduced by Delord et al. [2] of these neurons based on the Hodgkin-Huxley formalism, varied the values of two parameters of the model, i.e. the maximal persistent sodium conductance (g<sub>NaP</sub>) and the leakage one (g<sub>l</sub>), and revealed the (g<sub>NaP</sub>, g<sub>l</sub>) parameter space supporting regenerative firing. The present study focused on another parameter of this model, i.e. the maximal fast sodium conductance (g<sub>Na</sub>), to investigate the (g<sub>NaP</sub>, g<sub>Na</sub>) parameter space involved in regenerative firing. When g<sub>Na</sub> was completely blocked, regenerative firing was suppressed. In addition, the g<sub>Na</sub> threshold necessary to induce regenerative firing was almost independent of the g<sub>NaP</sub> level. Finally, our results were compared with those of other types of neurons.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz |
| Depositing User: | Ágnes Sallai |
| Date Deposited: | 27 Mar 2017 10:46 |
| Last Modified: | 28 Mar 2017 07:09 |
| URI: | http://real.mtak.hu/id/eprint/50543 |
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