Comparative study concerning mistletoe viscotoxins antitumor activity

Stan, Roxana and Hangan, Adriana and Dican, Lucia and Sevastre, B. and Hanganu, Daniela and Catoi, C. and Sarpataki, Orsolya and Ionescu, Corina (2013) Comparative study concerning mistletoe viscotoxins antitumor activity. Acta Biologica Hungarica, 64 (3). pp. 279-288. ISSN 0236-5383

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Viscum album L. (Santalaceae) (VA) — a parasitic plant that grows on various trees — has proved a significant anticancer effect in both experimental studies and clinical trials. The present study assesses the influence of oxidative stress in mistletoe induced cytotoxicity in tumor cells, in relation to classic cytostatic therapy. VA ethanolic extract was administered alone and combined with doxorubicin (chloride) in Swiss female mice previously intraperitoneally (i.p.) inoculated with Ehrlich tumor cells (1 × 10<sup>6</sup>/animal) that consequently developed Ehrlich ascites carcinoma (EAC). The administered doses were of 50 mg/kg on the 1<sup>st</sup>, 3<sup>rd</sup> and 6<sup>th</sup> day for the VA extract, respectively of 2.5 mg/kg on the 1<sup>st</sup> and 6<sup>th</sup> day for doxorubicin, after tumor cell implantation. Fourteen days later all mice were euthanized, ascites of the EAC were collected in order to analyze the tumor proliferation parameters, as well as blood samples, in order to evaluate the antioxidant status in plasma. Tumor development was associated with increased activity of plasma enzymes; classic doxorubicin therapy not only prevents the accumulation of ascitic fluid, but also significantly reduces the activity of plasma antioxidant enzymes. Furthermore, in association with VA extract, the protective effect is improved. Oxidative changes in Ehrlich tumor cells consisted in decreased catalase activity and amplified xanthine oxidase and peroxidase activities.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz
Depositing User: Ágnes Sallai
Date Deposited: 20 Apr 2017 06:58
Last Modified: 20 Apr 2017 06:58

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