Left atrium systolic and diastolic function assessment in hypertensive patients with preserved ejection fraction

Agoston-Coldea, Lucia and Lupu, S. and Hicea, S. and Mocan, T. (2013) Left atrium systolic and diastolic function assessment in hypertensive patients with preserved ejection fraction. Acta Physiologica Hungarica, 100 (2). pp. 140-152. ISSN 0231-424X

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Abstract

Left atrium remodeling is a physiological response to pressure overload in hypertensive patients. The aim of this study is to determine the relationship between left atrium remodeling and left ventricle diastolic dysfunction in hypertensive patients with preserved systolic function. Materials and Methods: We conducted a prospective study on 96 hypertensive patients (48.75 ± 5.01 years, 50 men) and 96 healthy control subjects (48.17 ± 8.52 years, 56 men), whose data were all evaluated by echocardiography measuring left atrium volumes during the reservoir, conduit and pump phases. Standard indices reflecting left ventricular filling were also prossessed. Results: Medium left atrium volume indexed for body surface was significantly higher in hypertensive patients – 30.87 (6.38) mL/m² vs. 21.72 (2.52) mL/m². Indexed left atrium volume was strongly associated with left ventricle diastolic function (p < 0.0001). When compared to normal subjects, patients with mild diastolic dysfunction had lower corrected passive emptying volumes (p < 0.0001) and higher corrected active emptying volumes (p = 0.001), thus leading to similar corrected total emptying volumes (p < 0.001). However, patients with moderate diastolic dysfunction had smaller active emptying volumes, but higher passive and total emptying volumes when compared to normal controls and patients with mild diastolic dysfunction. Conclusions: Left atrium indexed volumes evaluation during the reservoir, conduit and pump phases proved to be essential for early diastolic dysfunction assessment in hypertensive patients.

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