ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia

Semsei, Ágnes F and Erdélyi, Dániel and Ungvári, Ildikó and Csagoly, Edit and Hegyi, Márta and Lautner-Csorba, Orsolya and Szabolcs, Judit and Fekete, György and Falus, András and Szalai, Csaba and Kovács, Gábor (2012) ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia. CELL BIOLOGY INTERNATIONAL, 36 (1). pp. 79-86. ISSN 1065-6995

Preview	Text ANT_cikk_cbi20110264-1.pdf Download (620kB) | Preview
	Text CBI20110264.pdf - Published Version Restricted to Registered users only Download (475kB) | Request a copy

Abstract

Anthracyclines are potent cytostatic drugs the correct dosage of which is critical to aviod possible cardiac side effects. ABCC1 (MRP1) is expressed in the heart and takes part in the detoxification and protection of the cells from toxic effects of xenobiotics, including anthracyclines. Our objective was to search for associations between left ventricular function and single nucleotide polymorphisms of the ABCC1 gene in children who received anthracycline chemotherapy. We analyzed data of 235 pediatric patients with acute lymphoblastic leukemia. Patients were followed up by echocardiography (median follow up 6.3 years). Nine polymorphisms in the ABCC1 gene were genotyped. The ABCC1 rs3743527TT genotype and rs3743527TT-rs246221TC/TT genotype combination were found to be associated with lower left ventricular fractional shortening (LVFS) after chemotherapy. Our results suggest that genetic variants in the ABCC1 gene could influence anthracycline induced left ventricular dysfunction.

Actions (login required)

Edit Item