Synthesis and utilization of nitroxide free radicals and their precursors as sensors and possibly biologically active molecules

Kálai, Tamás (2017) Synthesis and utilization of nitroxide free radicals and their precursors as sensors and possibly biologically active molecules. Project Report. UNSPECIFIED, Pécs. (Unpublished)

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Abstract

Nitroxide stable free radicals have found broad app lication as spin labels, low molecular weight antioxidants, MRI contrast agents, co-oxidants, red ox- and pH-sensitive probes and mediators of polymerization. The chemistry of nitroxides invo lves many challenging aspects, including reaction for carbon-carbon bond formation in the pr esence of amphiphilic nitroxide moieties or the synthesis of nitroxide containing hybrid molecu les, for example, nitroxide incorporated biologically active molecules. In the frame of OTKA 104956 project we aimed to achieve new double (spin and fluorescent) redox sensor molecule s and accomplish the synthesis of new paramagnetically modified biomolecules, spin labels , complex forming agents. All these modifications had to be conducted with selective, b ut still more or less effective reactions.

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