Knyihar-Csillik, E. and Tajti, J. and Mohtasham, S. and Sáry, Gyula and Vécsei, L. (1995) Electrical stimulation of the Gasserian Ganglion induces structural alterations of calcitonin gene-related peptide-immunoreactive perivascular sensory nerve terminals in the rat cerebral dura mater: a possible model of migraine headache. NEUROSCIENCE LETTERS, 184. pp. 189-192. ISSN 0304-3940
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Abstract
Calcitonin gene-related peptide (CGRP)- positive sensory nerve fibers in the rat supratentorial cerebral dura mater are equipped with varicosities and club-like nerve terminals, often attached to the walls of blood vessels. Brief electrical stimulation of the Gasserian ganglion results in significant swelling and increased immunohistochemical staining of ipsilateral perivascular club-like terminals, while long-lasting electrical stimulation induces their disintegration or bursting, resulting in irregular, corroded outlines of terminals and en passant beads. Stimulation-induced morphological alterations of perivascular terminals may represent a structural basis of increased CGRP content in jugular blood which follows electrical stimulation of the Gasserian ganglion and accompanies migraine attacks.
Item Type: | Article |
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Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 15 Jul 2013 08:50 |
Last Modified: | 15 Jul 2013 08:50 |
URI: | http://real.mtak.hu/id/eprint/5940 |
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