Peptaibols and Related Peptaibiotics of Trichoderma. A review

Szekeres, A. and Leitgeb, B. and Kredics, L. and Antal, Zsuzsanna and Hatvani, L. and Manczinger, L. and Vágvölgyi, Cs. (2005) Peptaibols and Related Peptaibiotics of Trichoderma. A review. Acta Microbiologica et Immunologica Hungarica, 52 (2). pp. 137-168. ISSN 1217-8950

Preview

Text amicr.52.2005.2.2.pdf Download (529kB) | Preview

Abstract

Peptaibols and the related peptaibiotics are linear, amphipathic polypeptides. More than 300 of these secondary metabolites have been described to date. These compounds are composed of 5-20 amino acids and are generally produced in microheterogeneous mixtures. Peptaibols and peptaibiotics with unusual amino acid content are the result of non-ribosomal biosynthesis. Large multifunctional enzymes known as peptide synthetases assemble these molecules by the multiple carrier thiotemplate mechanism from a remarkable range of precursors, which can be N-methylated, acylated or reduced. Peptaibols and peptaibiotics show interesting physico-chemical and biological properties including the formation of pores in bilayer lipid membranes, as well as antibacterial, antifungal, occasionally antiviral activities, and may elicit plant resistance. The three-dimensional structure of peptaibols and pep­taibiotics is characterized predominantly by one type of the helical motifs a-helix, 3₁₀-helix and b-bend ribbon spiral. The aim of this review is to summarize the data available about the biosynthesis, biological activity and conformational properties of peptaibols and peptaibiotics described from Trichoderma species.

Actions (login required)

Edit Item