Subacute sclerosing panencephalitis in Croatia (1994–2004)

Vilibic Cavlek, Tatjana and Ljubin Sternak, Suncanica and Kaic, Bernard and Zarkovic, Kamelija and Marusic Della Marina, Branka and Cvitanovic Sojat, Ljerka and Basnec, Anica and Mlinaric Galinovic, Gordana (2007) Subacute sclerosing panencephalitis in Croatia (1994–2004). Acta Microbiologica et Immunologica Hungarica, 54 (1). pp. 57-63. ISSN 1217-8950

Text amicr.54.2007.1.6.pdf Restricted to Repository staff only until 31 March 2027. Download (61kB)

Abstract

We studied five patients with SSPE during a 10-year period (1994–2004). The first clinical symptoms developed at the age of 5–11 years. All patients were vaccinated regularly against measles according to the official immunization schedule. One patient had measles at the age of 18 months. Two of them had a history of morbilliform rash (unrecognized measles) at the age of six and seven months, respectively. In two patients, with no history of measles before vaccination the disease started after varicella infection.Using complement-fixation (F) test and EIA, antibodies to measles virus (MV) were detected in the CSF and sera of all patients. The CF-antibody titers ranged from 1:1024 to 1:65536 in sera and from 1:16 to 1:128 in CSF samples. MV antigen was detected in brain imprints using IFA in two patients. Electron microscopic analysis revealed intranuclear viral inclusions (MV nucleocapsids). Using RT-PCR, viral RNA was found in both patients. Nucleotide sequence analysis showed that the viruses found in the brain tissue belonged to the wild-type MV D6 genotype [7].

Actions (login required)

Edit Item