In Vitro activity of conventional antifungal agents against Scedosporium apiospermum isolates recovered from clinical and environmental samples in Nigeria

Nweze, E. I. and Okafor, J. I. (2010) In Vitro activity of conventional antifungal agents against Scedosporium apiospermum isolates recovered from clinical and environmental samples in Nigeria. Acta Microbiologica et Immunologica Hungarica, 57 (3). pp. 209-214. ISSN 1217-8950

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Abstract

In vitro susceptibilities of Scedosporium apiospermum isolates recovered from clinical and environmental samples in Nigeria were tested against ten conventional antifungal agents, namely: amphotericin B, nystatin, flucytosine, itraconazole, posaconazole, fluconazole, voriconazole, micafungin, ketoconazole, and terbinafine using the CLSI M38-A broth dilution reference method. The isolates showed varied response/sensitivities to the antifungal agents tested. This is probably the first documented testing of Scedosporium apiospermum isolates from Africa in general and Nigeria in particular against a broad range of conventional antifungal agents.

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