Recombinant Mycobacterium smegmatis vaccine candidates

Faludi, Ildikó and Szabó, Ágnes Míra and Burián, Katalin and Endrész, Valéria and Miczák, A. (2011) Recombinant Mycobacterium smegmatis vaccine candidates. Acta Microbiologica et Immunologica Hungarica, 58 (1). pp. 13-22. ISSN 1217-8950

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Abstract

Mycobacterium smegmatis is a species of rapidly growing saprophytes with a number of properties that make it an effective vaccine vector. Recombinant M. smegmatis expressing protective antigens of different pathogens and molecules modulating the immune responses offers some potential for reduction of the burden of tuberculosis, HIV and hepatitis B infections. This paper discusses the molecular methods used to generate recombinant M. smegmatis and the results obtained with some of these recombinants.

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