Cuparencu, B. and Tomus, C. and Gozariu, Manuela and Cuprian, Alina (2000) Effects of ICI 118.551, a selective beta-2 adrenergic blocking agent on the guinea pig cardic excitability and ventricular fibrillation threshold. Acta Physiologica Hungarica, 87 (1). pp. 113-126. ISSN 0231-424X
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Abstract
In isolated guinea pig perfused hearts ICI 118.551, a selective beta 2 adrenoceptor antagonist, induced transient ventricular extrasystoles. Following the termination of the perfusion, a very significant increase of both the ventricular fibrillation threshold and the refractory periods were measured. In guanethidine pretreated hearts, ICI 118.551 failed to induce premature beats. At the same time the fibrillation threshold and refractory periods exhibited a very significant decrease. The perfusion of equimolecular concentration of metoprolol, a beta-1-adrenoceptor antagonist, and (+) propranolol, a quinidine-like compound, induced, in most experimental settings, similar results as ICI 118.551. Thus, besides its beta-2-adrenoceptor antagonist properties, ICI 118.551 presented other pharmacological actions.
Item Type: | Article |
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Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
Depositing User: | xFruzsina xPataki |
Date Deposited: | 22 Oct 2017 08:20 |
Last Modified: | 31 Aug 2020 23:15 |
URI: | http://real.mtak.hu/id/eprint/63329 |
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