Binding capacity of rat liver glucocorticoid receptor in different periods after single neonatal benzpyrene treatment (imprinting)

Csaba, G. and Inczefi-Gonda, Ágnes (2001) Binding capacity of rat liver glucocorticoid receptor in different periods after single neonatal benzpyrene treatment (imprinting). Acta Physiologica Hungarica, 88 (2). pp. 125-129. ISSN 0231-424X

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Abstract

Newborn rats of both sexes were treated (imprinted) with 20mg of benzpyrene. Two hours, 2 days, 1, 2, 3 weeks, 1 month and 2 months after imprinting the liver glucocorticoid receptors were studied for binding of dexamethasone. Two-hour and 2-day values were not appreciable. One week after treatment the receptor's affinity was extremely low both in control and treated treated animals. Two weeks after imprinting a significant difference in density (lower) and affinity (higher) was observed between the male treated and control animals. At 3 weeks and one month the binding capacity of treated and control animals was equal however, at 2 months Bmax of males increased and that of females decreased significantly in the neonatally benzpyrene treated animals. This means that for the development of perinatal imprinting effect a long time is needed, and the effect is manifested after a period of lability.

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