Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction

Pajtás, Dávid and Kónya, Krisztina and Kiss-Szikszai, Attila and Džubák, Petr and Pethő, Zoltán and Varga, Zoltán and Panyi, György and Patonay, Tamás (2017) Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction. JOURNAL OF ORGANIC CHEMISTRY, 82 (9). pp. 4578-4587. ISSN 0022-3263

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Abstract

The article describes the development of Buchwald-Hartwig amination of different bromoflavones with amino acid and peptide derivatives as nitrogen source giving unique structures. The previously observed racemization, which occurred during the synthesis of flavone-amino acid hybrids, was successfully prevented in most cases. The biological assays of these novel structures showed cytotoxic effects on different cancer cell lines.

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