Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats

Fedotova, Julia O. and Hartmann, G. and Lénárd, L. and Sapronov, N.S. (2004) Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats. Acta Physiologica Hungarica, 91 (3-4). pp. 185-196. ISSN 0231-424X

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Abstract

The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptor antagonist NAN-190 (0.1 mg/kg, i.p.) injected for 14 days alone or in combination with 17µ-estradiol (0.5 µg i.m./rat/day) was studied on passive avoidance performance (PAR) and on behavior in the open field test in adult intact and ovariectomized (OVX) female rats. Administration of 5-HT1A receptor antagonist NAN-190 alone significantly improved PAR (p<0.05) in intact females with proestrus and estrus and in OVX females. Administration of 5-HT1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol significantly (p<0.05) improved PAR in OVX rats and failed to normalize PAR in intact rats with proestrus and estrus. Results of the work specify the involvement of 5-HT1A receptors in the mechanisms of passive avoidance learning in OVX female rats.

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