Márián, Teréz and Balkay, L. and Fekete, I. and Lengyel, Zs. and Veress, G. (2001) HYPOGLYCEMIA ACTIVATES COMPENSATORY MECHANISM OF GLUCOSE METABOLISM OF BRAIN. Acta Biologica Hungarica, 52 (1). pp. 35-45. ISSN 0236-5383
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Abstract
The effect of plasma glucose concentration on the cerebral uptake of [18 F]-fluorodeoxy-D-glucose (FDG) was studied in a broad concentration range in a rabbit brain model using dynamic FDG PET measure- ments. Hypoglycemic and hyperglycemic conditions were maintained by manipulating plasma glucose applying i.v. glucose or insulin load. FDG utilization (K) and cerebral glucose metabolic rate (CGMR) were evaluated in a plasma glucose concentration range between 0.5 mM and 26 mM from the kinetic constant k1, k2, k3 obtained by the Sokoloff model of FDG accumulation. A decreasing set of standard FDG uptake values found with increasing blood glucose concentration was explained by competition between the plasma glucose and the radiopharmacon FDG. A similar trend was observed for the forward kinetic constants k1, and k3 in the entire concentration range studied. The same decreasing tendency of k2 was of a smaller magnitude and was reverted at the lowest glucose concentrations where a pronounced decrease of this backward transport rate constant was detected. Our kinetic data indicate a modulation of the kinetics of carbohydrate metabolism by the blood glucose concentration and report on a special mechanism compensating for the low glucose supply under conditions of extremely low blood glucose level.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QH Natural history / természetrajz |
Depositing User: | Endre Sarvay |
Date Deposited: | 30 Oct 2017 08:53 |
Last Modified: | 30 Apr 2021 23:18 |
URI: | http://real.mtak.hu/id/eprint/66503 |
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