Concentration- and time-dependent effectof aminooxyacetic acidon cortical epileptogenicity

Barna, Barbara and Szász, A. and Asztalos, T. and Szupera, Z. and Vécsei, L. and Houtzager, Helmi and Szente, Magdolna (2002) Concentration- and time-dependent effectof aminooxyacetic acidon cortical epileptogenicity. Acta Biologica Hungarica, 53 (3). pp. 245-256. ISSN 0236-5383

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Abstract

In the present electrophysiological study the effect of aminooxyacetic acid (AOAA) on the cortical epileptogenicity, and on the basic electro-cortical activity was investigated in anesthetized rats.AOAA did not induce spontaneous epileptiform discharges but modified the somato-sensory evoked responses and the cortical epileptogenicity (induced by 4-aminopyridine) in the same manner depending on its concentration. AOAA at low concentrations increased the amplitude of evoked responses and the ipsilateral manifestation of epileptiform activity, however, at high concentrations significantly suppressed both the evoked responses and the induction and expression of seizures discharges. The anticonvulsive effect of AOAA was time-dependent (reached its maximum after 2h AOAA pre-treatment) and reversible. AOAA at low concentrations probably increases the efficacy of the NMDA excitatory system and decreases GABA-synthesis, resulting neuronal hyperexcitation. However, AOAA at high concentrations can lead to an effective cortical inhibition through intra- and extracellular accumulation of GABA. The gradual GABA accumulation - up to a certain level - at the synapses could also explain the time-dependency of the anticonvulsive effect of AOAA.

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