The P2Y nucleotide receptors in the human genome

Simon, J. and Barnard, E. A. (2003) The P2Y nucleotide receptors in the human genome. Acta Biologica Hungarica, 54 (2). pp. 191-201. ISSN 0236-5383

Preview

Text abiol.54.2003.2.8.pdf Download (472kB) | Preview

Abstract

Since the first identification of P2Y receptor sequences in 1993, it has quickly become apparent that this family of the G-protein coupled receptors is very diverse. Members of this receptor family are activated extra-cellularly by a wide variety of adenosine and uridine nucleotides including sugar-nucleotides. The recent decipherment of the Human Genome has enabled us to search for new, yet undiscovered P2Y receptor subtypes. In this article we examine the relationships of six orphan G-protein coupled receptor (GPCR) sequences which show considerable sequence homology to various P2Y receptors. The clustering at a few chromosomal loci of P2Y receptor genes and their related orphan genes further suggests that particular P2Y subsets were derived from the same ancestral gene during evolution.

Actions (login required)

Edit Item