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Stimulus frequency dependence of the central and peripheral somatosensory evoked activity in rats treated with various pesticides

Szabó, Andrea and Papp, A. and Nagymajtényi, L. (2005) Stimulus frequency dependence of the central and peripheral somatosensory evoked activity in rats treated with various pesticides. Acta Biologica Hungarica, 56 (3-4). pp. 205-214. ISSN 0236-5383

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Abstract

Rats were treated with a combination of insecticide agents in different timing schemes. In acute admin- istration, 1/5 LD 50 of the three insecticides: dimethoate, propoxur and cypermethrin, or their combina- tion, was given once by gavage. In the developmental model, female rats received oral doses of 1/25 LD 50 of the above insecticides in combination in three timing schemes including pregnancy and lacta- tion. Responses in the somatosensory cortex and in the tail nerve, evoked by peripheral electric stimula- tion, were recorded in acute preparation under urethane anesthesia. It was tested whether the parameters of the cortical and peripheral evoked response are dependent on the frequency and whether this depen- dence is different in control and treated animals. The latency increase of the cortical responses with increasing stimulation frequency was significantly stronger in rats treated acutely with cypermethrin and the combination, and in rats receiving the combination during both intra- and extrauterine development. On the duration, the effects were less clear. Frequency dependent increase of the tail nerve action poten- tial latency was significantly intensified by cypermethrin, and the amplitude decrease, by cypermethrin and dimethoate. Fatigue of this response during a stimulation series was also altered by the insecticides. Frequency dependence and fatigue possibly reflect the actual state of the nervous system and may have the potency to be developed to functional biomarkers.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz
Depositing User: Endre Sarvay
Date Deposited: 20 Nov 2017 14:08
Last Modified: 20 Nov 2017 14:08
URI: http://real.mtak.hu/id/eprint/70051

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