Mogulkoc, R. and Baltaci, A. K. and Oztekin, E. and Ozturk, A. and Sivrikaya, A. (2005) Short-term thyroxine administration leads to lipid peroxidation in renal and testicular tissues of rats with hypothyroidism. Acta Biologica Hungarica, 56 (3-4). pp. 225-232. ISSN 0236-5383
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Abstract
Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p<0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QH Natural history / természetrajz |
Depositing User: | Endre Sarvay |
Date Deposited: | 20 Nov 2017 14:09 |
Last Modified: | 20 Nov 2017 14:09 |
URI: | http://real.mtak.hu/id/eprint/70053 |
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