A study on the antioxidant activities of some new benzazole derivatives

Temiz-Arpaci, O. and Coban, T. and Tekiner-Gulbas, B. and Can-Eke, B. and Yildiz, I. and Aki-Sener, E. and Yalcin, I. and Iscan, M. (2006) A study on the antioxidant activities of some new benzazole derivatives. Acta Biologica Hungarica, 57 (2). pp. 201-209. ISSN 0236-5383

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Abstract

The in vitro antioxidant properties of some new benzazole derivatives ( 1–10 ) such as benzoxazoles, ben- zimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH- dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2- diphenyl-1-picrylhydrazyl (DPPH). Compounds 1 , 2 , 4 and 6 , showed potent scavenging effect on super- oxide radical at 10 –3 M. Compound 8, 5-nitro-2-(phenoxymethyl)benzimidazole, strongly inhibited lipid peroxidation at 10 –3 M concentration.

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