Evaluation of ketamine systemic absorption from topical preparations

Zapantis, G. and Zapantis, G. and Csóka, Ildikó and Csányi, E. and Csányi, E. and Horváth, G. and Horváth, G. and Erős, I. and Erős, I. (2006) Evaluation of ketamine systemic absorption from topical preparations. Acta Biologica Hungarica, 57 (3). pp. 387-389. ISSN 0236-5383

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The aim of this study was to evaluate the systemic absorption of the topically administered ketamine using different vehicles and additives, in order to develop a transdermal therapeutic system (TTS) of this drug. After the application of different ketamine preparations (1% in hydrogel, o/w cream, or organogel) the ketamine appeared in the blood. The lowest level could be observed with o/w cream, while the highest concentration was achieved by means of the hydrogel system, however this difference was not significant. Further studies are going to be performed with higher drug concentrations for the characterization of the differences in the pharmacodynamics of the drug with different vehicles and to evaluate the correlation between the in vitro and in vivo absorption.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz
Depositing User: Endre Sarvay
Date Deposited: 20 Nov 2017 14:32
Last Modified: 20 Nov 2017 14:32

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