Subchronic heavy metal and alcohol treatment in rats: Changes in the somatosensory evoked cortical activity

Lukács, Anita and Lengyel, Zsuzsanna and Institóris, L. and Szabó, Andrea (2007) Subchronic heavy metal and alcohol treatment in rats: Changes in the somatosensory evoked cortical activity. Acta Biologica Hungarica, 58 (3). pp. 259-267. ISSN 0236-5383

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Abstract

Young adult male Wistar rats were treated, by gavage, with 80 or 320 mg/kg Pb 2+ (lead acetate), 0.4 or 1.6 mg/kg Hg 2+ (mercuric chloride) or both by combining the lower doses. For combination with alco- hol, ethanol was added to the rats’ drinking water in 5 v/v %. After 12 weeks of treatment, electrophys- iological recording was made from the somatosensory cortex in urethane anaesthesia. Evoked potentials obtained by stimulation of the whiskers were recorded. Both metals, and alcohol alone, increased signif- icantly the latency of the evoked response. Alcohol seemed to abolish the effect of Pb, but not of Hg. Fatigue, calculated form the response amplitude, was increased by Pb and Hg treatment and this effect of Hg was reduced by ethanol. Evoked activity and its dynamic characteristics were sensitive to the com- plex neurotoxic effect induced in the rats and can provide a basis for developing functional markers

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