THE EFFECT OF CHRONIC DIAZEPAM ADMINISTRATION ON LIPID PEROXIDATION AND CA 2+ -ATPASE ACTIVITY IN RAT LIVER

Seçkin, Şule and Alsancak, Şeyda and Başaran-Küçükgergin, Canan and Uysal, Müjdat (2007) THE EFFECT OF CHRONIC DIAZEPAM ADMINISTRATION ON LIPID PEROXIDATION AND CA 2+ -ATPASE ACTIVITY IN RAT LIVER. Acta Biologica Hungarica, 58 (4). pp. 441-443. ISSN 0236-5383

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Abstract

Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH) content. DZP also markedly lowered Ca 2+ ATPase activity. Treatment with Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased lipid peroxidation together with alteration in Ca 2+ -ATPase activity may play a role in DZP induced hepat- ic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxi- city.

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