Monitoring of neuroactive factors released from a pattern-generating network

Chistopolsky, I. and Vorontsov, D. and Sakharov, D. (2008) Monitoring of neuroactive factors released from a pattern-generating network. Acta Biologica Hungarica, 59 (Supple). pp. 29-31. ISSN 0236-5383

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Abstract

To detect neuroactive factors in biological fluids, we have previously elaborated a moveable biosensor, the preparation of isolated neuron penetrated with recording microelectrode [1]. Here, we report that, in the pond snail, signals emanated from a central pattern generator (CPG) for feeding and detected by such biosensor correspond to long-term changes in motor output of the CPG as recorded from buccal nerves. The results suggest that combined recording from motor nerves, neurons in situ and the neuron-based biosensors may be a useful tool in studies of the mechanisms underlying network organisation.

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