Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1

Athayde Moncorvo Collado, Alejandro de and Corbalán, Natalia and Homolya, László and Morero, Roberto and Minahk, Carlos (2013) Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1. FEBS Letters, 587. pp. 2359-2363. ISSN 0014-5793

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Abstract

ABCG1 is a half-sized transporter with an unquestionable importance in cholesterol homeostasis. So far, its expression and thus its activity was suggested to be regulated at transcriptional level by LXR and PPAR agonists including polyphenols. However, it is unknown whether there are other mechanisms of up-regulation of ABCG1 activity. In the present work resveratrol was shown to induce a nearly twofold increase in ATPase activity of reconstituted ABCG1. Evidence is presented for the first time suggesting that resveratrol is able to activate ABCG1 activity by an alternative mechanism that involves an indirect interaction. © 2013 Federation of European Biochemical Societies.

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