Characterization of two different toxins of Wickerhamomyces anomalus (pichia anomala) VKM Y-159

Farkas, Z. and Márki-Zay, J. and Kucsera, Judit and Vágvölgyi, Cs. and Golubev, W. and Pfeiffer, Ilona (2012) Characterization of two different toxins of Wickerhamomyces anomalus (pichia anomala) VKM Y-159. Acta Biologica Hungarica, 63 (2). pp. 277-287. ISSN 0236-5383

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Abstract

Wickerhamomyces anomalus VKM Y-159 strain produces two types of toxin designated as WAKT a and WAKT b, encoded by chromosomal genes. The WAKT a toxin is heat-labile, pronase sensitive acting in pH range 3–4 affecting on several yeasts including pathogenic Candida species while the WAKT b toxin is protease- and thermo-resistant, acting in pH range 3–7 on two species, Candida alai and Candida norvegica. The rapid decrease of the number of viable cells after toxin treatment demonstrates that both toxins have cytocidic effect.

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