Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats

Literáti-Nagy, Zsuzsanna and Tory, Kálmán and Literáti-Nagy, Botond and Bajza, Ágnes and Vígh, László and Mandl, József and Szilvássy, Zoltán (2013) Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats. Pathology and Oncology Research, 19 (3). pp. 571-575. ISSN 1219-4956

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Abstract

Abdominal obesity is referred for as a common pathogenic root of multiple risk factors, which include insulin resistance, dyslipidemia, hypertension, and a pro-atherogenic and pro- inflammatory state. Irrespective of its psychiatric side effects, rimonabant through blocking cannabinoid-1 receptor (CB1R) induces an increase in whole body insulin sensitivity. The aim of this work was to study the effect of selected doses of another insulin sensitizer compound BGP-15, and rimonabant on insulin resistance in Zucker obese rats with a promise of inducing insulin sensitization together at lower doses than would have been expected by rimonabant alone. We found that BGP- 15 potentiates the insulin sensitizing effect of rimonabant. The combination at doses, which do not induce insulin sensitization by themselves, improved insulin signaling. Furthermore our results suggest that capsaicin-induced signal may play a role in insulin sensitizing effect of both molecules. Our data might indicate that a lower dose of rimonabant in the treatment of insulin resistance and type 2 diabetes is sufficient to administer, thus a lower incidence of the unfavorable psychiatric side effects of rimonabant are to be expected.

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