Vereczki, Viktória and Mansour, Josef and Pour-Ghaz, Issa and Bodnár, Ibolya and Pintér, Ottó and Oszwald, Erzsébet and Ádám, Veronika and Chinopoulos, Christos (2017) Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice. Mitochondrion, 34. pp. 115-126. ISSN 1567-7249, ESSN: 1872-8278
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Abstract
Abstract Cyclophilin D (cypD) modulates the properties of the permeability transition pore, a phenomenon implicated in the manifestation of many diseases including aging. Here, we examined the effects of partial or complete deletion of cypD on i) lifespan, ii) forebrain protein expression of 18 aging markers as well as regional expression of GFAP, mGluR1, and alpha-synuclein, and iii) behaviour of aged (> 24 month) male and female mice. Both male and female cypD heterozygous but not KO mice exhibited increased lifespans compared to WT littermates, associated with alterations in the protein expression of some markers, albeit without exhibiting changes in behaviour.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Mitochondria; heterozygote; PERMEABILITY TRANSITION; ALPHA-SYNUCLEIN; mGluR1; GFAP |
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 12 Mar 2018 12:30 |
| Last Modified: | 12 Mar 2018 12:31 |
| URI: | http://real.mtak.hu/id/eprint/78015 |
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