Coronavirus infection retards the development of the cortico-medullary capillary network in the bursa of Fabricius of chicken

Farsang, Attila and Bódi, Ildikó and Fölker, Orsolya and Minkó, Krisztina and Benyeda, Zsófia and Bálint, Ádám and Kiss, Anna L. and Oláh, Imre (2018) Coronavirus infection retards the development of the cortico-medullary capillary network in the bursa of Fabricius of chicken. Acta Veterinaria Hungarica, 66 (1). pp. 20-27. ISSN 0236-6290

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Abstract

Coronavirus infection delays the development of the cortico-medullary (CM) capillary network which results in retarded development of bursal follicles. The smaller size of the medulla in the coronavirus-infected birds may lead to a lower number of B lymphocytes and bursal secretory dendritic cells, which negatively affects the reactivity and efficacy of the immune system. Contrary to the wild-type infectious bronchitis virus (IBV) strain, infection induced by H120 vaccine virus exerts only a moderate influence on caveolin-1 expression of the CM capillary web and on follicular development compared to the untreated controls.

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