Are the MDS-UPDRS-based composite scores clinically applicable?

Makkos, Attila and Kovács, Márton and Aschermann, Zsuzsanna and Harmat, Márk and Janszky, József Vladimír and Karádi, Kázmér and Kovács, Norbert (2018) Are the MDS-UPDRS-based composite scores clinically applicable? MOVEMENT DISORDERS, 33 (5). pp. 835-839. ISSN 0885-3185

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Abstract

BACKGROUND: The International Parkinson and Movement Disorder Society-sponsored UPDRS (MDS-UPDRS) is a powerful clinical outcome measure. OBJECTIVES: To evaluate the feasibility of various MDS-UPDRS-based composite scores and determine their minimal clinically important difference threshold values. METHODS: Overall, 1,113 paired investigations of 452 patients were reviewed implementing three different techniques simultaneously. RESULTS: Based on the ordinal regression modeling, the MDS-UPDRS II+III, MDS-UPDRS I+II+III, and the total score of MDS-UPDRS are clinically applicable outcome measures. Any improvement greater than 4.9 points or any worsening more than 4.2 points on MDS-UPDRS II+III represent a minimal, yet clinically meaningful, change. In reference to MDS-UPDRS I+II+III, the smallest changes considered clinically relevant were 6.7 and 5.2 points for improvement and deterioration, respectively. The thresholds for the total score of MDS-UPDRS were 7.1 points for improvement and 6.3 points for worsening. CONCLUSIONS: Our findings support the application of various MDS-UPDRS-based composite scores. (c) 2018 International Parkinson and Movement Disorder Society.

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