The first characterized carbapenem-resistant Bacteroides fragilis strain from Croatia and the case study for it

Bogdan, Maja and Perić, Ljilijana and Ördög, Katalin and Vuković, Dubravka and Urbán, Edit and Sóki, József (2018) The first characterized carbapenem-resistant Bacteroides fragilis strain from Croatia and the case study for it. Acta Microbiologica et Immunologica Hungarica, 65 (3). pp. 317-323. ISSN 1217-8950

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Abstract

An imipenem-resistant Bacteroides fragilis strain was isolated from the blood of a 72-year-old male patient with a urinary bladder tumor in Osijek, Croatia. This strain was also resistant to ampicillin, piperacillin/tazobactam, cefoxitin, clindamycin, tetracycline, and harbored cfiA, ermF, and tetQ genes where the high-level expression of the cfiA carbapenem-resistant gene was driven by an IS1187 element. Interestingly, despite the carbapenem-resistant feature of the B. fragilis from blood, the patient relatively easily recovered from the bacteremia. It was the first characterized imipenem-resistant B. fragilis isolate with its case report from Croatia, which confirmed the appearance of carbapenem-resistant B. fragilis strains, that continues worldwide with low incidence and the molecular characteristics vary temporally and geographically.

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