Sági, B and Késői, I and Késői, B and Vas, T and Csiky, B and Kovács, T and Nagy, J (2018) Arterial stiffness may predict renal and cardiovascular prognosis in autosomal-dominant polycystic kidney disease. Physiology International, 105 (2). pp. 145-156. ISSN 2498-602X
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Abstract
<sec sec-type="background"> Background and aims Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common causes of end-stage renal disease (ESRD). The most important cause of death among ADPKD patients is cardiovascular (CV). The aim of this study was to examine the prognostic significance of arterial stiffness on CV and renal outcomes in ADPKD. Methods A total of 55 patients with ADPKD were examined. Pulse wave velocity was determined and stiffness index (SI<sub>DVP</sub>) was calculated. Combined primary endpoints (CV and renal) were major CV events (myocardial infarction, stroke, and CV intervention) as CV endpoints, and attaining of ESRD or start of renal replacement therapy as renal endpoints. Secondary endpoints were CV or renal endpoints separately. Results The mean age of those 55 ADPKD patients was 45 ± 12 years, 21 patients were male. The average value of the SI<sub>DVP</sub> was 11.11 ± 2.22 m/s. The patients were divided into two groups by the cutoff value of 11 m/s of SI<sub>DVP</sub> and then outcomes were analyzed. In the higher arterial stiffness group (SI<sub>DVP</sub> > 11 m/s), occurrence of combined primary endpoint (CV and renal) was significantly higher than in the group with more elastic arteries (p = 0.033). A statistically significant difference was found in the renal endpoints (p = 0.018), but not in the CV endpoints (p = 0.952) between the two groups. Conclusions Increased arterial stiffness predicts the onset of ESRD in ADPDK. Assessment of SI<sub>DVP</sub> appears to be a useful method for estimating the renal and CV prognosis in ADPKD.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában |
| Depositing User: | Eszter Bálint |
| Date Deposited: | 23 Aug 2018 11:10 |
| Last Modified: | 31 Jul 2019 23:15 |
| URI: | http://real.mtak.hu/id/eprint/82934 |
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