Al(OH)(3) facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

Cui, X. and Green, M. A. and Blower, P. J. and Zhou, D. and Yan, Y. and Máthé, Domokos and Veres, Dániel and Szigeti, Krisztián (2015) Al(OH)(3) facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles. CHEMICAL COMMUNICATIONS, 51 (45). pp. 9332-9335. ISSN 1359-7345

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Abstract

Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)(3)-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with F-18. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with Cu-64.

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